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New strategy designed by scientists to treat diabetes

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Baba Health Tips

There are few treatments for type 2 diabetes which make the body more susceptible to insulin – a hormone that will lower the blood sugar. However, a new research at the Washington University School of Medicine in St. Louis has found a different and effective strategy by slowing the making of glucose in the human liver.

Experiments were performed with mice where researchers showed the reduction of glucose production in the liver is possible that will eventually lower the blood sugar levels. Actually, a liver protein responsible for the production of glucose was shut down as an approach to make it work in type 2 diabetes patients.

Brian N. Finck, principal investigator and associate professor of medicine in the division of Geriatrics and Nutritional Science, said the strategy could lead to the production of more effective drugs for the treatment of type 2 diabetes. With the help of researchers at the Texas University and the biopharmaceutical company Metabolic Solutions Development Co., the group of Finck is involved in scientific trials to evaluate drug compound MSDC-0602 for diabetes treatment. In the study, it can be seen how the compound works by slowing down the production of a protein which is responsible for glucose production in the human body.

Moreover, a research team which is led by Kyle S. McCommis, a postdoctoral research scholar and first author, showed how the sugar production in liver cells is cut by inhibiting the protein essential for the transportation of pyruvate, from the bloodstream to the energy factories found in liver cells called mitochondria.

Earlier, studies warned obstructing pyruvate may limit the production of glucose in the liver but however, the new study demonstrated the importance of transporting pyruvate protein.

Additionally, researchers believe pyruvate transportation can come handy for patients with nonalcoholic fatty liver disease which is common in obese people.

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